Individuals who have appeared on One Life to Live. This includes contract, recurring and day player roles.
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- Saundra Santiago
- Paul Satterfield
- Sherri Saum
- Stephen Schnetzer
- Marnie Schulenburg
- Jason-Shane Scott
- Paolo Seganti
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- John Wesley Shipp
- Jeremy Slate
- Erika Slezak
- Hillary B. Smith
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- Gillian Spencer
- Kevin Spirtas
- Trevor St. John
- Timothy D. Stickney
- Jim Storm
- Michael Storm
- Robin Strasser
- Shepperd Strudwick
- Anna Stuart
- Mary Stuart
- Tika Sumpter
- Michael Swan